Reduction of myocardial ischaemia–reperfusion injury by inactivating oxidized phospholipids

Inflammatory profile of oxidized phospholipids.

Lipid oxidation products and in particular oxidized phospholipids (OxPL) are increasingly recognized as inducers of chronic inflammation characteristic of atherosclerosis. OxPL stimulate production of chemokines and adhesion of monocytes to endothelial cells. However, accumulating data suggest that, in addition to the proatherogenic and proinflammatory effects, OxPL can stimulate antiinflammato...

Biophysical Characterization of Oxidized Phospholipids

A great variety of biochemical processes are either confined to or mediated by cellular membranes constructed around a framework provided by a compositionally heterogeneous and highly dynamic bilayer of phospholipid molecules. Accordingly, the physical properties and molecular organization of these mesoscopic supramolecular assemblies are regarded to represent pivotal determinants of the overal...

Oxidized phospholipids protect against lung injury and endothelial barrier dysfunction caused by heat-inactivated Staphylococcus aureus.

Increased endothelial cell (EC) permeability and vascular inflammation along with alveolar epithelial damage are key features of acute lung injury (ALI). Products of 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine oxidation (OxPAPC) showed protective effects against inflammatory signaling and vascular EC barrier dysfunction induced by gram-negative bacterial wall lipopolysaccharide (L...

Network for Activation of Human Endothelial Cells by Oxidized Phospholipids

The role of oxidized phospholipids in atherosclerosis.

There is increasing evidence that oxidized phospholipids (OxPLs) play an important role in atherosclerosis. These phospholipids accumulate in human and mouse lesions. Specific OxPLs have been identified as major regulators of many cell types present in the vessel wall. In endothelial cells, >1,000 genes are regulated. Some of these genes are pro-atherogenic and others anti-atherogenic. The anti...